Noncanonical function of DGCR8 controls mESC exit from pluripotency
نویسندگان
چکیده
منابع مشابه
Noncanonical function of DGCR8 controls mESC exit from pluripotency
Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present strong differentiation defects. However, the exact reasons impairing their commitment remain elusive. The analysis of newly generated mutant mESCs revealed that DGCR8 is essential for the exit from the pluripotency state. To dissociate canonical versus noncanonical functions of DGCR8, ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2017
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201606073